Run DataTable To Keep Track Of Best Score

I've made a computer game in Visual Basic Express 2008 and my only remaining problem is to run a data table to keep a running track of the best score. To do this I've created a datatable form called BestScore.xsd. My first problem here is to recognize that it should will start off with nil values and I need to initialize it to zero. Next I need to update the score. I will need to save the score when I exit the game. (Does VBE automatically save the datatable or there a command here?). When I reopen the game program I want it to find my best score from last time.